This presentation will explore the core components of normal neurodevelopment and how they are altered in autism, with a particular focus on the role of neuroinflammation in driving the severity and progression of the disorder. A key aspect of early childhood brain development is myelination, and this lecture highlights the critical role of plasmalogen biosynthesis—an essential membrane lipid in the brain—in maintaining myelination. Disruptions in plasmalogen biosynthesis, coupled with excessive plasmalogen biosynthesis demand, lead to impaired myelination and disrupted neurodevelopment, which are central to the pathophysiology of autism. Neuroinflammation is identified as a primary cause of dysmyelination and impaired neurodevelopment in autism, exacerbating the condition. The lecture emphasizes advanced brain nutrition strategies aimed at restoring neurodevelopment, focusing on plasmalogen precursor supplementation to restore myelination and support brain function. Additionally, the importance of restoring methyltransferase and mitochondrial capacity, alongside general supportive nutrition, is discussed as part of a comprehensive intervention strategy for autism. By addressing these key biological factors, this approach aims to improve neurodevelopmental outcomes in individuals with autism.