This lecture explores a functional and integrative pediatric approach to autism spectrum disorder (ASD), focusing on root-cause interventions. Topics include the benefits of casein- and gluten-free diets, the impact of glyphosate on gut health, and the role of the vagus nerve and polyvagal theory in regulating emotional and physiological responses. Birth trauma, bacterial and fungal imbalances, and cerebral folate deficiency are discussed as contributing factors to neurological and behavioral symptoms. The lecture also highlights methylation challenges and the importance of personalized supplementation, including plant-based bio-nutrients, to support detoxification, cellular health, and brain function. These strategies aim to optimize outcomes and enhance the quality of life for children with ASD.